Cardinals Face Week 6 Uncertainty as Kyler Murray Battles Foot Injury

The NFL Arizona Cardinals are entering Week 6 with major uncertainty under center. Quarterback Kyler Murray is officially listed as questionable for Sunday’s matchup against the Indianapolis Colts, following a week of limited practice activity.

After missing Wednesday and Thursday’s sessions, Murray returned on Friday in a limited role a sign of progress but not a guarantee he’ll play.

For a team already on a three-game losing streak, the potential absence of their star quarterback couldn’t come at a worse time.

Murray’s Impact on the Cardinals’ Offense

When healthy, Kyler Murray is the heartbeat of the Arizona Cardinals offense both through the air and on the ground.

This season, he’s completed 68.3% of his passes, throwing for 962 yards, six touchdowns, and three interceptions. On top of that, he leads the team in rushing yards with 173 yards on 29 carries proving once again how critical his dual-threat ability is to Arizona’s attack.

If Murray can’t go, the Cardinals’ offense loses its most dynamic weapon and that changes everything against a tough Colts defense.

Backup Plan: Jacoby Brissett Steps In

If Kyler Murray’s injury sidelines him this week, Jacoby Brissett will step up as the starter.

Brissett, 32, is a veteran presence who’s been around the league, but his recent experience is limited. So far this season, he’s taken only four snaps and attempted just one pass.

Last year with the Patriots, Brissett went 1–4 as a starter, completing 59% of his throws for 826 yards, two touchdowns, and one interception.

While Brissett brings leadership and poise, his lack of recent playing time raises questions about how well he can command the Arizona Cardinals NFL offense against a 4–1 Colts team.

Colts Defense Could Be a Nightmare Matchup

The Indianapolis Colts aren’t making things easy for anyone this season.

They currently rank third in scoring defense and allowing just 17.8 points per game, and are tied for fifth in takeaways (8) and sacks (14) through five games.

For a struggling Cardinals offense already missing running backs James Conner and Trey Benson, so the matchup looks even tougher without Murray.

If Brissett starts, expect the Cardinals to rely more heavily on short passes and quick reads to keep the Colts’ front seven from dominating the pocket.

What’s at Stake for Arizona

This game is critical for the NFL Arizona Cardinals.

A win could stop the losing streak and bring some momentum back into the locker room. A loss, however, might push them deeper into the NFC West standings and raise more questions about how this team plans to turn things around in 2025.

Whether or not Murray plays, the Cardinals will need to show resilience something that’s been missing since their early-season win.

Game Details

  • Matchup: Arizona Cardinals vs Indianapolis Colts
  • Venue: Lucas Oil Stadium
  • Date: Sunday, October 12, 2025
  • Time: 1:00 PM ET
  • Watch: NFL Network / Local Broadcast

Final Thoughts

The Kyler Murray injury update leaves Arizona fans holding their breath ahead of Sunday’s game.

If Murray plays, even at less than 100%, he gives the Arizona Cardinals NFL football team a fighting chance. If not, Jacoby Brissett will have to step up big time to keep Arizona’s offense moving.

Either way, this Week 6 matchup against the Colts could be a turning point for the Cardinals’ season for better or worse.

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