Introduction

Baltimore, Maryland, also known as Charm City, is a vibrant destination filled with historic neighborhoods, stunning waterfront views, and a dynamic food scene. Whether you’re planning a weekend in Baltimore as a history buff, foodie, or culture enthusiast, the city offers an unforgettable experience.

If you’re spending just 48 hours in Baltimore, this carefully curated weekend itinerary will guide you through the city’s must-visit attractions, best restaurants, and hidden gems—ensuring you make the most of your time.

Day 1: Exploring the Inner Harbor & Historic Neighborhoods

Morning: Arrival & Breakfast at Blue Moon Café

Start your Baltimore adventure with a hearty breakfast at Blue Moon Café in Fells Point. This local favorite is known for its decadent Captain Crunch French Toast and oversized cinnamon rolls. If you’re craving something savory, their crab eggs benedict is a must-try.

Location: 1621 Aliceanna St, Baltimore, MD

Late Morning: Inner Harbor & National Aquarium

After breakfast, head to Baltimore’s Inner Harbor, the city’s iconic waterfront district. Stroll along the scenic Harbor Promenade and take in the views before diving into one of Baltimore’s top attractions:

  • National Aquarium – Home to over 20,000 marine animals, including sharks, jellyfish, and the famous Australia exhibit. Allocate at least 2 hours to fully explore the exhibits.

Location: 501 E Pratt St, Baltimore, MD

Lunch: Seafood at Thames Street Oyster House

No trip to Baltimore is complete without fresh seafood, and Thames Street Oyster House is one of the best spots to indulge. Located in Fells Point, this cozy seafood restaurant offers delicious Maryland blue crabs, lobster rolls, and raw oysters.

Location: 1728 Thames St, Baltimore, MD

Afternoon: Explore Historic Fells Point & Take a Water Taxi

After lunch, wander through the cobblestone streets of Fells Point, one of Baltimore’s oldest neighborhoods. Highlights include:

  • Boutique Shopping – Visit local stores like Su Casa for home décor and Sound Garden for vinyl records.
  • The Horse You Came In On Saloon – The oldest continuously operating saloon in America, rumored to be the last place Edgar Allan Poe was seen before his death.

From here, hop on a Baltimore Water Taxi and cruise around the harbor for a unique perspective of the city.

Evening: Dinner & Nightlife in Harbor East

For dinner, head to Charleston in Harbor East, an upscale fine-dining restaurant offering Southern-inspired cuisine with an elegant touch. Their tasting menu paired with wine is a must for foodies.

Location: 1000 Lancaster St, Baltimore, MD

After dinner, end the night with a cocktail at The Bygone, a rooftop bar offering breathtaking skyline views.

Location: 400 International Dr, Baltimore, MD

Day 2: History, Art & Local Eats

Morning: Breakfast at Miss Shirley’s Café

Kick off your second day with breakfast at Miss Shirley’s Café, an award-winning brunch spot famous for its Southern comfort food. Try the crab cake & fried green tomato eggs benedict or their legendary Cinnamon Danish pancakes.

Location: 750 E Pratt St, Baltimore, MD

Late Morning: American Visionary Art Museum

After breakfast, visit the American Visionary Art Museum (AVAM)—one of the most unique museums in the country. This museum showcases quirky, self-taught artists’ works, including massive sculptures and interactive exhibits.

Location: 800 Key Hwy, Baltimore, MD

Lunch: Lexington Market for Local Eats

For an authentic taste of Baltimore, head to Lexington Market, one of the oldest public markets in America. Try:

  • Faidley’s Seafood: Home to Baltimore’s best crab cakes
  • Berger’s Bakery: Famous for iconic Berger cookies

Location: 112 N Eutaw St, Baltimore, MD

Afternoon: Visit Fort McHenry

No trip to Baltimore is complete without visiting Fort McHenry, the birthplace of the Star-Spangled Banner. Learn about the fort’s role in the War of 1812 and enjoy a scenic walk along the waterfront.

Location: 2400 E Fort Ave, Baltimore, MD

Evening: Sunset at Top of the World Observation Deck

For the best panoramic views of Baltimore, visit the Top of the World Observation Deck at the World Trade Center Baltimore. Catch a stunning sunset over the harbor before dinner.

Location: 401 E Pratt St, Baltimore, MD

Final Dinner: Cozy Italian at La Scala

Wrap up your weekend with authentic Italian cuisine at La Scala Ristorante in Little Italy. Known for its homemade pasta and intimate ambiance, it’s the perfect way to end your trip.

Location: 1012 Eastern Ave, Baltimore, MD

Summary

After an exciting weekend in Baltimore, you’ll leave with unforgettable memories of the city’s vibrant culture, rich history, and diverse culinary scene. From exploring historic neighborhoods to indulging in fresh seafood and iconic eats, Baltimore offers something for every traveler. Whether you’re admiring waterfront views or discovering hidden gems, each moment captures the charm of this dynamic city. A carefully planned itinerary ensures you make the most of your visit. Start planning your next weekend in Baltimore to experience all that Charm City has to offer.